What is  EDOX® ?

 EDOX®   is an effective, natural and safe dietary supplement whose benefit for  enhancing sexual performance has been clinically proven in multiple  scientific publications. 

EDOX®  consists of a patented combination of two clinically tested  potent ingredients, L-Arginine aspartate and Pycnogenol® . These  important nutrients help protect, restore, and sustain endothelial  function, increase nitric oxide levels and improve vascular integrity  and blood flow to the genital region. Through these mechanisms Edox®   naturally enhances erectile function as well as sexual performance.  Edox®  taken daily will restore your sexual confidence and provide  sexual wellness for you and your partner.

The Ingredients comprising EDOX® : L-Arginine, L-Citrulline and Pycnogenol®
L-Arginine and L-Citrulline are amino acids that are utilized by the  human body to produce nitric oxide. Nitric oxide is the primary mediator  responsible for the enhancement of vascular flow throughout the body  including penile erections. Pycnogenol®  is a natural product derived  from the bark of the French maritime pine tree and has been demonstrated  in clinical studies to regulate the performance of the enzyme that  converts L-Arginine into nitric oxide. L-Citrulline converts to  L-Arginine after supplementationTherefore, the patented combination of  L-Arginine aspartate, L-Citrulline malate, and Pycnogenol®  found in  EDOX®  works synergistically to enhance erectile function and sexual  performance.

Why EDOX® ?
EDOX®   is an all-natural product comprised of the patented combination of  Pycnogenol® , L-Arginine and L-Citrulline which has not shown signs of  toxicity or harmful side effects. Furthermore, EDOX®  is safe,  effective, beneficial and often less expensive than many of the other  therapies for improving sexual performance. In addition to improving  sexual performance, Pycnogenol®  is a potent antioxidant with numerous  additional health care benefits that include improvement in fertility  status and enhancement of overall cardiovascular health. 

These statements have not been evaluated by the  Food and Drug Administration. This product is not intended to diagnose,  treat, cure or prevent any disease.

In  numerous scientific publications describing clinical studies conducted  in both the United States and Europe, the combination of Pycnogenol®  and L-Arginine has demonstrated efficacy in increasing and enhancing  sexual pleasure and performance. A testament to the unassailable  scientific evidence supporting the effectiveness of EDOX®  is that the  combination of Pycnogenol® and l-Arginine has been granted a patent  (US6,565,851 B2) for the relief of the symptoms of ED. Several of these  studies are summarized below.

Treatment of Erectile Dysfunction with Pycnogenol® and L-Arginine
Stanislavov R. et al. Journal of Sex and Marital Therapy, 29(3) 207-213, 2003

40  men (aged 25-45 years) with erectile dysfunction of at least 3 months  duration were studied. Initially these men where treated with L-Arginine  alone for one month, and a poor response was achieved whereby only 5%  of the men experienced normal erectile function. However, when  Pycnogenol® was added to the regiment, a significant improvement was  noted. After one month of 80 mg of Pycnogenol®/day, 80% of the men  reported normal erections. This response  improved in a dose dependant  fashion whereby increasing the Pycnogenol® dose to 120 mg per day,  92.5% of the men experienced a return of normal erectile function.  Furthermore, the study demonstrated that as one increased the dose of  Pycnogenol®, the time to achieve an erection decreased and the duration  of the erection increased. At a dose of 120 mg of Pycnogenol®, the  duration of the erection increased to 15 ® 3 minutes. No adverse side  effects were reported by the men taking Pycnogenol® and L-Arginine. The  study concluded that  Supplementation with arginine and Pycnogenol®  on a regular basis renders individuals with ED to be healthy lovers with  a satisfying sexuality.

Prelox For Improvement of Erectile Function: A Review
Lamm S. et al. European Bulletin of Drug Research 11 (3), 29-37, 2003

In a United States study performed by Dr. Steven Lamm, 37 men with  erectile dysfunction who where prospectively given therapy with  L-Arginine and Pycnogenol® were analyzed. 81% of the men reported that  treatment with L-Arginine and Pycnogenol®had improved their ability to  engage in sexual activity. An increased IIEF score was reported in 70%  of the men with a 10% mean IIEF score increase for the study group as a  whole. 73% of the men reported that L-Arginine and Pycnogenol® made it  easier to initiate an erection and 70% stated that it made it easier to  sustain an erection. A sub analysis of the study population revealed  that L-Arginine and Pycnogenol® demonstrated increased efficacy  particularly in men who at baseline suffered from moderate and mild  erectile dysfunction. In the subgroup of men having the mildest forms of  erectile dysfunction, complete restoration of their sexual function was  observed. No adverse side effects were reported by the men taking  Pycnogenol® and L-Arginine. The authors concluded that L-Arginine and  Pycnogenol®?is effective for preserving healthy sexual function in  aging men experiencing first signs of lowered erectile performance. 

Improvement of Erectile Function with Prelox®: A Randomized Double-Blind, Placebo Controlled, Crossover Trial
Stanislavov R. et al. International Journal of Impotence Research Mar-Apr; 20(2) 173-80, 2008 

50  men (aged 30-50 years) with ED were treated in a prospective double  blind fashion for one month either with placebo or a combination of  L-Arginine and 80 mg of Pycnogenol®. At the conclusion of the initial  treatment  month, the two groups were crossed over whereby the original  placebo group then received L-Arginine and 80 mg of Pycnogenol®, and  the initially treated group then received placebo for an additional  month. At the conclusion of the treatment period, men treated with  L-Arginine and Pycnogenol® achieved normal erectile function (normal  defined as an IIEF score of > 25). The treated men reported improved  IIEF scores from 11-17 to 26-30.  Those treated with placebo did not  demonstrate a significant improvement in erectile function. On average  it took approximately 5 days for the combination of L-Arginine and  Pycnogenol® to improve erectile performance. The mean number of  intercourse events more than doubled while on study drug. In the  specific IIEF domains of orgasmic function, sexual desire, and  intercourse satisfaction, significant improvement was reported.  The  study also noted that the improvement in erectile function following  L-Arginine and Pycnogenol® intake extended beyond the treatment period,  suggesting a sustained effect. Furthermore, in this study total  testosterone levels also significantly improved in the group of men  taking L-Arginine and Pycnogenol®. No adverse side effects were  reported by the men taking Pycnogenol® and L-Arginine. The authors  concluded that treatment with L-Arginine and Pycnogenol® seems to  offer a safe and very effective alternative to existing medications for the treatment of erectile dysfunction. 

Endothelium Dependant Vascular effects of Pycnogenol®.
Fitzpatrick D.F et al. Journal of Cardiovascular Pharmacology 32, 509-515, 1998 

Pycnogenol® is a very powerful antioxidant that has been shown to  stimulate nitric oxide synthesis. Nitric oxide is the key biological  compound responsible for penile smooth muscle relaxation and  vasodilatation resulting in erectile function. 

These statements have not been evaluated by the  Food and Drug Administration. This product is not intended to diagnose,  treat, cure or prevent any disease.

What Is Erectile Dysfunction?

Erectile  dysfunction (ED) also knows as impotence is the inability to attain and  retain an erection that is firm enough for a man to have intercourse,  or the inability to maintain an erection long enough to ejaculate inside  the vagina.

It can happen in one of two ways:

• A man may be unable to get an erection.
• A man may lose his erection at some point during intercourse, before he ejaculates.

A man is considered to have erectile dysfunction if he is unable to  get or maintain an erection in at least 50 percent of his attempts at  intercourse.

Erectile dysfunction is a problem for both the man and his partner.  In many cases, treatment may not be necessary and the ED may resolve to  some degree. In others, it may remain an issues that requires treatment.

Anything that interferes with either by reducing the blood flow to  the penis or increasing the blood flow out of it – can cause erectile  dysfunction. Fear, anxiety, anger, or any other strong emotion can  interrupt the signal from the brain. An illness or physical condition  can also impair erections if it interferes with this chain of events. 

In most men, erectile dysfunction does not change their sexual desires, ejaculation or orgasms once he achieves and erection. 

Is It Physical Or Mental?
It was believed for many years psychological factors were responsible  for many of cases of erectile dysfunction. Due to new diagnostic methods  and more sophisticated equipment, the conclusion is that physical  factors are the main cause in the majority of cases. Due to the brains  involvement it does play an important role in sexual activity, thus the  body and mind are connected as one. 

How Common Is It?
Erectile  dysfunction is common problem through a man's lifetime. Most of the  men by the age of 50 years old have experiences erectile dysfunction at  some point in time. According to the Massachusetts Male Aging Study  complete impotence increases from 5% at the age of 40 to 15% of the  males in the age group over 70 years or older. In a study conducted in  the Netherlands the occurrence of some form of erectile dysfunction  occurred in 20% of the males between ages50-54 and in 50% of the males  between 70-78 years of age. 

Although sexual activity normally continues throughout a man’s  lifetime, his reactions take longer as he ages. He may need more  stimulation to get an erection. He may take longer to climax, and he may  need to wait longer before he can get another erection.

The chance of erectile dysfunction does increase with age. But  erectile dysfunction can affect men at any age and at any time in their  lives.

What Are the Options For Erectile Dysfunction?
There are many options for erectile dysfunction in the vast majority of  individuals. Most men regain their ability to have intercourse using one  of the following options:

• Working with doctors to selection a medication or other option that can assist in gain back erectile function
• Making lifestyle changes (eg. Quitting smoking, lowering alcohol  intake, exercising more, improve diet intakes of vegetables and fruits,  among other)
• Counseling
• Natural supplements and anti-oxidants 
• Taking ED medications
• Vacuum constrictive devices
• Injections and implants
• 
  

How Does Erection Normally Happen?
An erection is a cascade of events that requires the interaction of the  brain, nerves, hormones, and blood vessels. This process is separate  from ejaculation and orgasm, both of which can occur without an erect  penis.

The brain starts the process that will produce an erection due to psychological or physical stimulation.

• As a result of, the brain sends messages through the nervous system to the penis. 
• These messages relax the smooth muscles in the blood vessel walls of  the corpus cavernosum (spongy tissue chambers running along the shaft  of the penis) by the release of nitric oxide, which causes them to open  wider.
• When this happens, nitric oxide allows this tissue to relax and fill  with up to sixteen times its normal capacity of blood, filling the  corpus cavernosum. 
• At the same time, pressure applied to the veins that carry blood  away from the penis shut down, restricting blood flow out of the penis. 
• The blood that is trapped within the corpus cavernosum causes the penis to become hard and erect.
• 
  

What Can Cause Erectile Dysfunction?
The ability to achieve and sustain erections requires

1. a healthy nervous system that conducts nerve impulses in the brain, spinal column, and penis,
2. healthy arteries in and near the corpora cavernosa,
3. healthy smooth muscles and fibrous tissues within the corpora cavernosa,
4. adequate levels of nitric oxide in the penis.

Erectile dysfunction can occur if one or more of these requirements are not met.

Some men are more likely to have erectile problems if they are put  under emotional or physical strain. In general, seven “triggers” are  linked with erectile dysfunction:

• Aging
• Illnesses
  • Diabetes
  • High blood pressure
  • Heart conditions
  • Poor circulation
  • Kidney failure
  • Thyroid deficiency
  • Multiple sclerosis
  • Chronic alcoholism
  • Spinal cord injury
  • Depression
• Physical conditions
• Stress related to a job, marriage, or finances is a common cause of  erection problems. Ongoing stress may result in erectile dysfunction,  which in turn increases stress.
• Certain medications that may affect erections include:
  • Nicotine (as in excessive smoking)
  • Alcohol
  • Cocaine, heroine, amphetamines, and other illegal drugs
  • Tranquilizers and sleeping pills
  • Antidepressants
  • Blood pressure medication (beta-blockers)
  • Heart medications (such as digoxin)
  • Some peptic ulcer medication (such as cimetidine)
• Misinformation
• Poor communication 
• A “vicious circle” 

Physical causes are more common in older men, while psychological causes are more common in younger men. 

• Medications are the cause in an estimated 25 percent of erectile dysfunction cases.
• Various illnesses account for up to 75 percent of those people with  ED. For example, up to 35 percent of diabetic males may experience  impotence at some stage
• 
  

Where To Find Help
The best person to approach is your own doctor, who might be able to  help you or who can recommend someone else. You may be referred to a  urologist, a medical specialist with advanced training to deal with  issues surrounding erectile dysfunction. 

Summary Of Important Information Related To Erectile Dysfunction

• Erectile dysfunction is common and treatable. 
• Treatment should involve a man’s partner as well, since erectile  dysfunction can have an impact on both of them and their relationship. 
• Although there is usually a mind-body connection with erectile dysfunction, the majority of cases have a physical cause. 
• Various “triggers” can cause erectile dysfunction; sometimes it is  the result of two or more of these triggers working together. 
• A wide variety of options are available for erectile dysfunction,  including medication, lifestyle changes, counseling, mechanical devices,  and surgery. 
• Because prevention is always better than cure, men should maintain healthy habits to help prevent erectile problems. 
• 
  

What Is Endothelium and Function Of Endothelial Cells?
The endothelium is a thin layer of cells that lines the surface of blood  vessels, forming an interface between circulating blood in the lumen  and the rest of the vessel wall. These cells that line the entire  circulatory system are called endothelial cells. The endothelial cells  create a smooth lining which decrease turbulent flow of blood through  the vessels. 

The involvement of Endothelial cells and its role in the body are as follows processes:

• Atherosclerosis
• Blood vessel 
• Blood clotting (thrombosis & fibrinolysis)
• Inflammation
• Formation of new blood vessels (angiogenesis)
• Vasoconstriction and vasodilation, thus controlling blood pressure
• Filtration – highly differentiated unique endothelial cells are found in the renal glomerulus and the blood-brain barrier.

What Is Endothelial Dysfunction?
Endothelial dysfunction is a state in which the endothelial lining and  the blood vessels do not respond well to vasodilating and  vasoconstricting substances like nitric oxide, which is produced by the  endothelium. Endothelial dysfunction can cause or be caused by many  diseases such as: hypertension, hypercholesterolemia, diabetes, or  environmental factors as alcohol intake, smoking tobacco products and  exposure to pollution.

Impaired or loss of  endothelial function is frequently seen in  patients with coronary artery disease, diabetes mellitus, hypertension,  hypercholesterolemia, as well as in smokers and may be early signs of  vascular disease or development of atherosclerosis.  There have been  many studies that show some correlation between endothelial dysfunction  and future cardiovascular events. Impaired nitric oxide production due  to oxidative stress or other mechanisms which damage the endothelial  cells are the main reasons for endothelial dysfunction. 

Is Endothelial Dysfunction Related to Cardiovascular Disease?
Endothelial dysfunction is thought to be a key event in the development  of atherosclerosis and predates clinically vascular disease sometime by  many years. The reduced anticoagulant properties, oxidative stress and  increased adhesion molecule expression are factors in the development of  arthrosclerosis which are seen in endothelial dysfunction. Endothelial  dysfunction has been shown to be of significance in predicting vascular  events including stroke and heart attacks. 

The Role of Nitric Oxide In Endothelial Dysfunction?
In endothelial dysfunction is the inability of arteries and arterioles  to dilate fully in response to release of vasodilators from the  endothelium like nitric oxide (NO). Endothelial dysfunction is commonly  associated with decreased NO bioavailability, which is due to impaired  NO production by the endothelium and/or increased inactivation of NO by  reactive oxygen species. This can be tested flow-mediated dilation,  which is the most widely used non-invasive test for assessing  endothelial function. This technique measures endothelial function by  inducing reactive hyperemic via temporary arterial occlusion and  measuring the resultant relative increase in blood vessel diameter via  ultrasound. People with endothelial dysfunction have low NO  bioavailability, their blood vessels have a decreased capacity to dilate  in response to certain stimuli, compared to those with normal  endothelial function.

Because NO has anti-inflammatory and anti-proliferative effects and  therefore helps inhibit atherosclerosis, it is easy to see how  endothelial dysfunction may contribute to future adverse cardiovascular  events. Due to the variability in such tests (e.g. due to time of day,  food, menstrual cycle, temperature, etc.) means that no technique has  yet been identified that would allow endothelial testing to attain  routine clinical significance, the Endo-PAT is being utilized now which  is a reproducible, user independent non-invasive diagnostic test, which  would limit the variability  of the test.  

What Are the Options For Improvement of Endothelial Dysfunction?
Exercise and improved diet has a significant impact on endothelial  function. A study published in 2005 has determined that a positive  relationship exists between the consumption of high fat diet and the  development of endothelial dysfunction. Lifestyle modifications can  improve endothelial function which include cessation of smoking, loss of  weight and treatment of hypertension and hypercholesterolemia amongst  other things. Some studies have found antioxidant and arginine  supplementation independently and in combination can help to restore  impaired endothelial dysfunction. Studies show that increasing nitric  oxide production by the endothelial cells can have a positive impact on  improving endothelial function. 

These statements have not been evaluated by the  Food and Drug Administration. This product is not intended to diagnose,  treat, cure or prevent any disease.

Why Should I considerEDOX®?
EDOX® is a safe, all natural, and scientifically documented method to  enhanced sexual performance.  EDOX® taken daily will restore your  sexual confidence and provide sexual wellness for you and your partner.   

Is EDOX® Safe?
Arginine and citrulline, are amino acids found in many foods, has been  shown to be safe in amounts as high as 30 grams.  Pycnogenol® is a  naturally occurring antioxidant with essentially no known toxicity.

Sources of Arginine and Citrulline in food:

Animal Proteins: are a source of  both arginine and citrulline,  however citrulline is found in very small amounts in these types of  foods. 

Plant Proteins: Grains, Vegetables, legumes, nuts and seeds also have  both but are also a better source for arginine than citruline. 

Watermelon however is a rich source of citrulline. 

Does EDOX®EDOX® Have Side Effects?
A small percentage of people may experience flushing or headaches when  they initially start using EDOX®. However, this should lessen with  continuing usage.  If you are seriously ill, on multiple medications,  suffer from sever hypertension or heart disease, consult with you  physician before using EDOX®. 

How Does EDOX® Work?
EDOX® is a patented proprietary blend of L-Arginine, L-Citrulline and  Pycnogenol®.  These important nutrients help protect, restore, and  sustain endothelial function, increase nitric oxide levels and improve  vascular integrity and blood flow to the genital region. Through these  mechanisms, EDOX® naturally enhances erectile function as well as  sexual performance. 

How Do I Take EDOX®?
The recommended dose is two tablets daily. The two tablets maybe taken at once a day or one tablet twice a day. 

Why Do I Need To Take EDOX® Daily?
The ingredients in EDOX® require a limited period of time to maximize  their effectiveness and prime the vascular system to become more  responsive. EDOX®s initial benefit is dependent on comorbidities  which include advancing age, smoking history, cardiovascular disease,  diabetes and other health issues associated with declining sexual  function. The majority of men will begin to experience improvement in  sexual performance during the initial 2-4 weeks of usage.  EDOX® is a  daily supplement and does not perform as medications do. Over a period  of time continued benefit of EDOX® is sustained with just two tablets  per day.

Will EDOX® Begin To Work Immediately?
L-Arginine begins working immediately to enhance penile blood flow with  resultant improvement in the quality and duration of an erection. The  maximum benefit of EDOX®, however, will accrue over an extended period  of time as the health of the vascular system continues to improve. 

How Long Does It Take To See A Maximum Benefit?
After four weeks of EDOX® usage, the blood vessel responsiveness should  have improved sufficiently for one to experience the maximum benefit.  At this juncture, one will become aroused and erect more easily and be  able to sustain an erection for a longer period of time. 

These statements have not been evaluated by the  Food and Drug Administration. This product is not intended to diagnose,  treat, cure or prevent any disease.

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