In  numerous scientific publications describing clinical studies conducted  in both the United States and Europe, the combination of Pycnogenol®  and L-Arginine has demonstrated efficacy in increasing and enhancing  sexual pleasure and performance. A testament to the unassailable  scientific evidence supporting the effectiveness of EDOX®  is that the  combination of Pycnogenol® and l-Arginine has been granted a patent  (US6,565,851 B2) for the relief of the symptoms of ED. Several of these  studies are summarized below.

Treatment of Erectile Dysfunction with Pycnogenol® and L-Arginine
Stanislavov R. et al. Journal of Sex and Marital Therapy, 29(3) 207-213, 2003

40  men (aged 25-45 years) with erectile dysfunction of at least 3 months  duration were studied. Initially these men where treated with L-Arginine  alone for one month, and a poor response was achieved whereby only 5%  of the men experienced normal erectile function. However, when  Pycnogenol® was added to the regiment, a significant improvement was  noted. After one month of 80 mg of Pycnogenol®/day, 80% of the men  reported normal erections. This response  improved in a dose dependant  fashion whereby increasing the Pycnogenol® dose to 120 mg per day,  92.5% of the men experienced a return of normal erectile function.  Furthermore, the study demonstrated that as one increased the dose of  Pycnogenol®, the time to achieve an erection decreased and the duration  of the erection increased. At a dose of 120 mg of Pycnogenol®, the  duration of the erection increased to 15 ® 3 minutes. No adverse side  effects were reported by the men taking Pycnogenol® and L-Arginine. The  study concluded that  Supplementation with arginine and Pycnogenol®  on a regular basis renders individuals with ED to be healthy lovers with  a satisfying sexuality.

Prelox For Improvement of Erectile Function: A Review
Lamm S. et al. European Bulletin of Drug Research 11 (3), 29-37, 2003

In a United States study performed by Dr. Steven Lamm, 37 men with  erectile dysfunction who where prospectively given therapy with  L-Arginine and Pycnogenol® were analyzed. 81% of the men reported that  treatment with L-Arginine and Pycnogenol®had improved their ability to  engage in sexual activity. An increased IIEF score was reported in 70%  of the men with a 10% mean IIEF score increase for the study group as a  whole. 73% of the men reported that L-Arginine and Pycnogenol® made it  easier to initiate an erection and 70% stated that it made it easier to  sustain an erection. A sub analysis of the study population revealed  that L-Arginine and Pycnogenol® demonstrated increased efficacy  particularly in men who at baseline suffered from moderate and mild  erectile dysfunction. In the subgroup of men having the mildest forms of  erectile dysfunction, complete restoration of their sexual function was  observed. No adverse side effects were reported by the men taking  Pycnogenol® and L-Arginine. The authors concluded that L-Arginine and  Pycnogenol®?is effective for preserving healthy sexual function in  aging men experiencing first signs of lowered erectile performance. 

Improvement of Erectile Function with Prelox®: A Randomized Double-Blind, Placebo Controlled, Crossover Trial
Stanislavov R. et al. International Journal of Impotence Research Mar-Apr; 20(2) 173-80, 2008 

50  men (aged 30-50 years) with ED were treated in a prospective double  blind fashion for one month either with placebo or a combination of  L-Arginine and 80 mg of Pycnogenol®. At the conclusion of the initial  treatment  month, the two groups were crossed over whereby the original  placebo group then received L-Arginine and 80 mg of Pycnogenol®, and  the initially treated group then received placebo for an additional  month. At the conclusion of the treatment period, men treated with  L-Arginine and Pycnogenol® achieved normal erectile function (normal  defined as an IIEF score of > 25). The treated men reported improved  IIEF scores from 11-17 to 26-30.  Those treated with placebo did not  demonstrate a significant improvement in erectile function. On average  it took approximately 5 days for the combination of L-Arginine and  Pycnogenol® to improve erectile performance. The mean number of  intercourse events more than doubled while on study drug. In the  specific IIEF domains of orgasmic function, sexual desire, and  intercourse satisfaction, significant improvement was reported.  The  study also noted that the improvement in erectile function following  L-Arginine and Pycnogenol® intake extended beyond the treatment period,  suggesting a sustained effect. Furthermore, in this study total  testosterone levels also significantly improved in the group of men  taking L-Arginine and Pycnogenol®. No adverse side effects were  reported by the men taking Pycnogenol® and L-Arginine. The authors  concluded that treatment with L-Arginine and Pycnogenol® seems to  offer a safe and very effective alternative to existing medications for the treatment of erectile dysfunction. 

Endothelium Dependant Vascular effects of Pycnogenol®.
Fitzpatrick D.F et al. Journal of Cardiovascular Pharmacology 32, 509-515, 1998 

Pycnogenol® is a very powerful antioxidant that has been shown to  stimulate nitric oxide synthesis. Nitric oxide is the key biological  compound responsible for penile smooth muscle relaxation and  vasodilatation resulting in erectile function. 

These statements have not been evaluated by the  Food and Drug Administration. This product is not intended to diagnose,  treat, cure or prevent any disease.

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